Shoshana Emanuel is the adopted sister of Ezekiel, Rahm, and Ari Emanuel. She was adopted as a newborn in 1973 by their parents, Benjamin and Marsha Emanuel, in the Chicago area, after Benjamin treated her as a pediatrician. Her adoption followed birth complications, including a brain hemorrhage that resulted in cerebral palsy, requiring multiple surgeries for improved mobility. As a young woman, she gave birth to two children, with her mother Marsha providing significant care; one child resided with her parents Benjamin and Marsha, and the other was adopted by her brother Ari Emanuel around 2015. Her relationship with her brothers is described as 'episodic,' with them acting as older uncles during her upbringing. The family maintains her privacy, limiting public details and omitting her from memoirs like Ezekiel's. Reports from the late 1990s portray her as proud of her brothers but keeping her distance, with family members speculating on factors contributing to her life challenges.