Mark L. Schusterman was the son of Charles and Lynn Schusterman, prominent figures in the American oil industry and philanthropy. Born into a wealthy family in Tulsa, Oklahoma, Mark grew up immersed in the world of family business and charitable endeavors. His father, Charles, founded the Samson Investment Company (later Samson Resources), which became one of the largest privately held oil and gas companies in the United States before its sale to Devon Energy in 2011. Mark was a former executive at Samson Resources and a key figure in the family philanthropy, serving on the board of the Charles and Lynn Schusterman Family Philanthropies, an organization focused on supporting Jewish causes, education, and community development in Oklahoma and beyond. He was also involved in family investments, contributing to the legacy of the Schusterman family's influence in business and nonprofit sectors.

Tragically, Mark Schusterman passed away at the young age of 35 in 1999, an event that profoundly affected his family. His death was ruled an accidental overdose involving cocaine and heroin, highlighting personal struggles amid the family's public success. This loss deeply impacted the family's personal and philanthropic outlook, deepening their commitment to philanthropy, particularly in areas related to health, education, and support for vulnerable populations. Mark's involvement in the family foundation prior to his death underscored his role as a bridge between the business empire and charitable initiatives, leaving a lasting impact on the organization's direction.