The Anti-Defamation League (ADL) has criticized ACT! for America and its leadership, including Guy Rodgers, for promoting what it describes as anti-Muslim and Islamophobic rhetoric and activities. The ADL has published reports and statements highlighting the organization's role in spreading Islamophobic narratives, which the ADL argues contribute to discrimination and hate against Muslim communities. While no direct legal action has been taken against Rodgers, the ADL's designation of ACT! for America as an extremist group has led to broader legal and reputational challenges for the organization.

Howard Kohr collaborated with the Anti-Defamation League (ADL) on initiatives to combat antisemitism and promote pro-Israel advocacy. AIPAC and ADL have worked together on campaigns to counter anti-Israel sentiment and support Jewish communities.

Goldwasser has collaborated with the Anti-Defamation League (ADL) on events and initiatives addressing anti-Israel activism and radical Islam, particularly in the context of campus advocacy and media projects. The ADL has engaged with Goldwasser's work in its broader efforts to counter extremism.

The ADL has accused Yoram Hazony of promoting ideas that align with far-right and extremist movements, particularly through his advocacy for national conservatism. The ADL has included Hazony's work in reports and statements warning about the rise of illiberal nationalism and its potential to fuel extremism.

The ADL publicly criticized Beck's on-air commentary about George Soros, saying it invoked antisemitic tropes and conspiracy theories

Robert Leikind was a salaried employee of the Anti-Defamation League (ADL) for approximately eight years, serving as the Regional Director for ADL Connecticut and later for ADL New England (Boston) from 2000 until at least 2004. He received professional compensation for his role leading legal and civil rights advocacy.