The United States Chamber of Commerce (USCC) is the largest business association and lobbying group in the United States, representing American business interests and advocating for pro-business policies on issues such as trade, taxation, labor, regulation, and innovation. Founded on April 23, 1912, in Washington, D.C., at a meeting of over 700 delegates from local chambers of commerce, the organization was spurred by President William Howard Taft's vision for a national entity to unify business voices and facilitate communication with the government. The first president was Harry A. Wheeler, with notable vice presidents including Joseph Nathan Teal and business leaders from major companies.

For over a century, the U.S. Chamber has served as a powerful advocate, influencing legislation to foster job creation and economic growth. Its membership spans a wide spectrum, from small businesses and local chambers to startups, industry associations, and multinational corporations, making it a comprehensive network that optimizes government-business relations at federal, state, and international levels. The Chamber engages in extensive lobbying, legal advocacy, and resource provision to help members navigate policy challenges, positioning itself as a trusted partner in improving societal and economic outcomes through business-friendly initiatives.

Headquartered in Washington, D.C., the USCC remains a dominant force in U.S. politics, often ranked as the top-spending lobbying organization, and continues to shape national discourse on issues like immigration reform, environmental regulations, and healthcare. It is often criticized for its influence on policy favoring large corporations and for dark money involvement in elections, while also drawing praise for defending free enterprise.