Elizabeth Santorum is the eldest daughter of former U.S. Senator Rick Santorum and author Karen Santorum, born into a prominent conservative political family. Raised in a household deeply committed to Catholic values, pro-life advocacy, and traditional family principles, she experienced the public spotlight early due to her father's political career in the U.S. House of Representatives (1991-1995) and Senate (1995-2007), as well as his presidential campaigns in 2012 and 2016. The family resided primarily in Pennsylvania during this period, later relocating to Virginia. Elizabeth has one sibling who passed away in infancy, Gabriel, in 1996, an event that profoundly influenced the family's advocacy work.

After graduating from George Washington University with a degree in political science, Elizabeth pursued a career in conservative media and advocacy. She served as communications director for the American Principles Project, a nonprofit focused on social conservative issues, and has contributed to outlets like Fox News and The Blaze, often discussing topics such as religious liberty, education reform, and opposition to same-sex marriage. Elizabeth co-founded PRISM, a conservative women's group aimed at engaging young women in public policy, and has authored articles and spoken at events for organizations like the Family Research Council. Her work aligns closely with her father's ideology, emphasizing limited government and Judeo-Christian ethics.

Beyond professional endeavors, Elizabeth maintains a low public profile regarding her personal life, though she remains active in conservative networks. She has been involved in family-authored books, such as contributing to narratives around their experiences with child loss and faith. As of recent years, she resides in the Washington, D.C. area, continuing to influence youth outreach in Republican circles.