Debra Lerner is an American business executive and philanthropist, serving as co-managing principal of Lerner Enterprises, the family-owned real estate development firm founded by her father, Ted Lerner, in 1952. As the sister of Mark D. Lerner and Nancy Lerner Speigel, she plays a key role in overseeing the company's extensive portfolio of commercial, residential, and mixed-use properties in the Washington, D.C. metropolitan area, which spans millions of square feet and includes landmark developments like Tysons Corner Center. Following Ted Lerner's death on February 12, 2023, Debra and her siblings assumed primary leadership of the firm, continuing its tradition of urban redevelopment and community-focused projects. The family's net worth, largely derived from these holdings, has been estimated in the billions, underscoring Debra's position within one of the most influential real estate dynasties in the United States.

In addition to her business responsibilities, Debra Lerner is involved in the family's ownership of the Washington Nationals Major League Baseball franchise, which they purchased in 2006 for $450 million. She contributes to the team's governance and charitable efforts, including initiatives through the Nationals Philanthropies. The Lerners are also deeply engaged in philanthropy, with Debra serving as a trustee for organizations such as the Morris and Gwendolyn Cafritz Foundation and supporting Jewish causes, education, and health programs via family foundations. Her work emphasizes quiet, impactful giving rather than public prominence, aligning with the family's low-key approach to wealth and influence.

Debra Lerner's career has been intertwined with the family enterprise since early adulthood, reflecting a commitment to preserving and growing the Lerner legacy. While maintaining a private personal life, her strategic involvement has helped navigate the company through economic shifts and expansions, solidifying its status as a pillar of D.C.'s business landscape. She is also a board member of the Jewish Federation of Greater Washington and has been involved with the United Jewish Endowment Fund, reflecting her deep ties to the local Jewish community. Debra holds a degree from the University of Maryland and has been recognized for her leadership in both business and philanthropic circles, though she typically avoids media attention.